Three major commercial streets form the border and one cuts through the middle of Tower Grove South, providing all the necessities for shopping, dining, and entertainment. There are numerous small shops and businesses scattered throughout the neighborhood as well.
- Grand South Grand - St. Louis' premier location for a variety of ethnic foods and shopping with an international flair.
- Morgan Ford Business District - A growing retail and dining destination with eclectic shops, bars, and restaurants.
- Gravois - A longtime commercial corridor, with a variety of offerings from groceries to Vietnamese cuisine.
- Kingshighway - Automobile sales and big box retail dominate this commercial corridor, but some local gems dot the landscape as well.
